Heteronuclear NMR

With much larger chemical shift dispersion and less background signals, hetronuclear NMR provides attractive alternative over proton for drug discovery and material research. For small molecules with severely overlapped proton spectra, you can expect 13C spectra should be well resolved, which will significantly facilitate your resonance assignment and structure elucidation.

Prof. Hupp and Farha’s group has been trying to find metal–organic framework (MOF) based catalysts which are capable of rapidly detoxifying nerve agents or used for the elimination of large stores of chemical warfare agents (CWAs).  Phosphorous (31P) NMR is their tool to monitor reactions in their research. The following figure is taken from one of their publications in this topic titled “Instantaneous Hydrolysis of Nerve-Agent Simulants with a Six-Connected Zirconium-Based Metal–Organic Framework” (Angewandte Chemie, 2015).



Check out the details about your nucleus from NMR Periodic Table before you start.

IMSERC NMR has the capability to do heteronuclear NMR data collection for any nucleus ranging from 10% (15N, Nitrogen) to 40% (31P, Phosphorous) of proton frequency, including 19F besides 1H and 13C. We have an unique HFX probe capable of running 2D 1H-19F correlation (HOESY) experiment. Other common nuclei our users do NMR on are Deuterium (D), Boron (B), Lithium (Li), Oxygen (O), Aluminium (Al), Silicon (Si), Tin (Sn), and Platinum (Pt).